Research

In addition to excellence in clinical care, the Critical Care Division at Egleston has demonstrated significant research productivity. The division experience encompasses projects reflecting study design and completion on a single center basis, as well as multi-institutional collaboration; and including bench, clinical and translational research.

We participate in Pediatric Acute Lung injury and Sepsis Investigators (PALISI). In recent years the CCM group has been engaged in the Therapeutic Hypothermia After Pediatric Cardiac Arrest (THAPCA) trial, HALF-PINT and CALF-PINT , a multi-center network of pediatric critical care units evaluating the course and outcomes of thrombocytopenia-associated multiple organ failure (TAMOF), and NEARS-4KIDS. Additionally research interests within the division include oxidative stress during sepsis, development of an innovative continuous renal replacement device, neuro-endocrine axis dysfunction, simulation in education, procedural sedation, sedation during ventilation, enteral feeding methodologies, tandem extracorporeal procedures, ECMO outcomes, continuous EEG monitoring, and markers in acute kidney injury quality improvement.

Emory University provides many avenues for research collaboration including: The CDC, the American Cancer Society, Emory University School of Public Health, VA Hospital, Georgia Institute of Technology and other divisions of the Emory Department of Pediatrics. Opportunities for further post-graduate training in conjunction with fellowship are available, but not required. Options exist to pursue a Master’s in Public Health (MPH) or a Master of Science in Clinical Research at Emory.

Principle investigators include:
James Fortenberry: Dr. Fortenberry is the CCM Division Research Director. Dr. Fortenberry's research interests include acute lung injury, pediatric septic shock, use of advanced technologies for support of organ failure, and outcomes research in protocol-based ICU care. He has a strong interest in extracorporeal life support and use in pediatric sepsis. He developed a multi-center network of pediatric critical care units evaluating the course and outcomes of thrombocytopenia-associated multiple organ failure (TAMOF) which tracks response to plasma exchange in these patients. He has authored a variety of studies related to management and outcomes with pediatric ECMO and CRRT, and management protocols. Dr. Fortenberry also serves as the division's PALISI representative and as site investigator for the CPCCRN critical pertussis initiative.

Kiran Hebbar: Dr. Hebbar's primary interest is focused in neuro-endocrine axis dysfunction critically ill children, particularly those with sepsis. He is currently evaluating the use of a steroid sepsis protocol in pediatric patients requiring vasopressors. He also directs the Pediatric Simulation (PEDSIM) experience for the residents and fellows.

Pradip Kamat: Dr. Kamat's interest is in the pediatric difficult airway. He is the site investigator for NEAR4kids project. Dr. Kamat is also the site investigator for the efficacy of Calfactant in immunocompromised children with respiratory failure and ARDS.

Matthew Paden: Dr. Paden's research interests are related to use of advanced technologies including extracorporeal membrane oxygenation (ECMO) and continuous renal replacement therapies (CRRT). Dr. Paden is currently funded by the National Institutes of Diabetes and Digestive and Kidney Diseases to develop KIDSCRRT, a novel neonatal & pediatric CRRT device with improved accuracy and reduced extracorporeal volume compared to currently available adult options. For the KIDSCRRT project, Dr. Paden is collaborating with Dr. Ajit Yoganathan & the Cardiovascular Fluid Dynamics Laboratory of the Department of Biomedical Engineering at The Georgia Institute of Technology. In other research, Dr. Paden has performed a prospective study evaluating the impact of institution of CRRT on inflammatory cytokines in children as well as an outcome study on patients treated withboth CRRT and ECMO. Dr. Paden is currently the site principal investigator in multiple PALISI studies evaluating the outcomes of pediatric patients with severe novel-H1N1 influenza infection.

Toni Petrillo: Dr. Petrillo's research interests have been primarily clinical research related to therapeutic approaches to the critically ill asthmatic patients including use of ketamine. She also has developed consensus protocols to enhance enteral feeding in pediatric ICU patients. she is currently working on the use of modified PEWS score in transport.

Nga Pham: Dr. Pham has been part of the THAPCA (Therapeutic Hypothermia After Pediatric Cardiac Arrest) study since 2011. This is a multi-center study sponsored by NHLBI to evaluate the long term benefit on neurological recovering with cooling after cardiac arrest.  Recent project is HALF-PINT and CALF-PINT.

Jana Stockwell: Dr. Stockwell is the Pediatric Critical Care Division Chief. Her primary interest is in Quality Improvement in the PICU and in the hospital at large, primarily in regards to prevention of catheter-associated blood stream infections, ventilator-associated pneumonia, and venous thromboembolic complications.

Atul Vats: Dr. Vats's research interests are focused on efficiency and resource optimization within the PICU and the hospital system, with a particular emphasis on physician workflow. In addition, Dr. Vats is studying the impact of a protocolized approach to sedation and analgesia (including daily sedation holidays) in intubated pediatric patients. Other projects include: understanding the impact of B-natriuretic peptide in pediatric critical illness, and analysis of exhaled breath condensate in intubated pediatric patients.

Emory University provides many avenues for research collaboration including:  The CDC, the American Cancer Society, Emory University School of Public Health, VA Hospital, Georgia Institute of Technology and other divisions of the Emory Department of Pediatrics. Opportunities for further post-graduate training in conjunction with fellowship are available, but not required.  Options exist to pursue a Master’s in Public Health (MPH) or a Master of Science in Clinical Research at Emory.