Research


Our research laboratory seeks to understand the fundamental mechanisms that
regulate cell adhesion in vascular cells and how these processes contribute to
hemostasis, cardiovascular disease and cancer. Using genetically-modified mice
and guided by structure-function analysis, we study how an important class of
adhesion receptors, integrins, are regulated in platelets and endothelial cells and, in turn, probe biological significance of these regulatory mechanisms. We believe that a better understanding of how integrin signaling is regulated and how these pathways contribute to disease will help us to identify novel therapeutic approaches in human disease.

p-lab
Wild type (above) and talin1- deficient (below) mouse platelets spreading on fibrinogen.
p-lab
Blood vessels of the adult mouse retina showing collagen IV+ basement membrane (blue) and smooth muscle cells (red)
p-lab
Whole mount image of adult mouse ear showing CD31+ endothelium (blue), VECAD-Cre/TdTomato+ endothelium (red) and Lyve-1+ lymphatic vessels (green).