Selected Publications



  1. Francis AC and Melikyan GB. Single HIV-1 Imaging Reveals Progression of Infection through CA-Dependent Steps of Docking at the Nuclear Pore, Uncoating, and Nuclear Transport. Cell Host Microbe. 2018 Apr 11;23(4):536-548.e6. doi: 10.1016/j.chom.2018.03.009. PMID:29649444.
  2. Sood C, Francis AC, Desai TM, Melikyan GB. An improved labeling strategy enables automated detection of single-virus fusion and assessment of HIV-1 protease activity in single virions. J. Biol. Chem. 2017 Dec 8;292(49):20196-20207. doi: 10.1074/jbc.M117.818088.
  3. Sood C, Marin M, Chande A, Pizzato M, Melikyan GB. SERINC5 Inhibits HIV-1 Fusion Pore Formation by Promoting Functional Inactivation of Envelope Glycoproteins. J. Biol. Chem. 2017 doi: 10.1074/jbc.M117.777714. [Epub ahead of print].
  4. Giroud C, Du Y, Marin M, Min Q, Jui NT, Fu H, Melikyan GB. Screening and Functional Profiling of Small-Molecule HIV-1 Entry and Fusion Inhibitors. Assay Drug Dev Technol. 2017 Feb/Mar;15(2):53-63. doi: 10.1089/adt.2017.777.
  5. Desai TM, Marin M, Mason C, Melikyan GB. pH regulation in early endosomes and interferon-inducible transmembrane proteins control avian retrovirus fusion. J. Biol. Chem. 2017. pii: jbc.M117.783878. doi: 10.1074/jbc.M117.783878.
  6. Francis AC, Marin M, Shi J, Aiken C, Melikyan GB. Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells. PLoS Pathogens 2016, 12(6):e1005709. doi: 10.1371/journal.ppat.1005709.
  7. Hampton CM, Strauss JD, Ke Z, Dillard RS, Hammonds JE, Alonas E, Desai TM, Marin M, Storms RE, Leon F, Melikyan GB, Santangelo PJ, Spearman PW, Wright ER. Correlated fluorescence microscopy and cryo-electron tomography of virus-infected or transfected mammalian cells. Nat. Protoc. 2017 Jan;12(1):150-167. doi: 10.1038/nprot.2016.168.
  8. Desai TM, Marin M, Sood C, Shi J, Nawaz F, Aiken C and Melikyan GB. Fluorescent protein-tagged Vpr dissociates from HIV-1 core after viral fusion and rapidly enters the cell nucleus. Retrovirology. 2015, 12:88. doi: 10.1186/s12977-015-0215-z.
  9. Giroud C, Marin M, Hammonds J, Spearman P and Melikyan GB. P2X1 receptor antagonists inhibit HIV-1 fusion by blocking virus-coreceptor interactions. J. Virol. 2015, 89:9368-9382.
  10. Kondo N, Marin M, Kim JH, Desai TM and Melikyan GB. Distinct requirements for HIV-cell and HIV-mediated cell-cell fusion. J. Biol. Chem. 2015, 290:6558-6573
  11. Padilla-Parra S, Marin M, Kondo N and Melikyan GB. Pinpointing retrovirus entry sites in cells expressing alternatively spliced receptor isoforms by single virus imaging. Retrovirology. 2014 11:47. doi: 10.1186/1742-4690.11-47
  12. Desai TM, Marin M, Chin CR, Savidis G, Brass AL and Melikyan GB. IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion. PLoS Pathog. 2014, 10(4):e1004048. doi: 10.1371/journal.ppat.1004048. PMCID: PMC3974867.
  13. Demirkhanyan L, Marin M, Lu W, Melikyan GB. Sub-Inhibitory Concentrations of Human α-defensin Potentiate Neutralizing Antibodies against HIV-1 gp41 Pre-Hairpin Intermediates in the Presence of Serum. PLoS Pathog. 2013 Jun;9(6):e1003431. doi: 10.1371/journal.ppat.1003431. Epub 2013 Jun 13. PMCID: PMC3681749.
  14. Padilla-Parra S, Matos PM, Kondo N, Marin M, Santos NC, and Melikyan GB. Quantitative imaging of endosome acidification and single retrovirus fusion with distinct pools of early endosomes. Proc. Natl. Acad. Sci. USA, 2012, 109:17627-17632.
  15. Miyauchi K., Kim Y., Latinovic O., Morozov V., and Melikyan G.B. HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes. Cell, 2009, 137:433-444.