Selected Publications



  1. Francis AC, Marin M, Shi J, Aiken C, Melikyan GB. Time-Resolved Imaging of Single HIV-1 Uncoating In Vitro and in Living Cells. PLoS Pathogens 2016, 12(6):e1005709. doi: 10.1371/journal.ppat.1005709.
  2. Hampton CM, Strauss JD, Ke Z, Dillard RS, Hammonds JE, Alonas E, Desai TM, Marin M, Storms RE, Leon F, Melikyan GB, Santangelo PJ, Spearman PW, Wright ER. Correlated fluorescence microscopy and cryo-electron tomography of virus-infected or transfected mammalian cells. Nat. Protoc. 2017 Jan;12(1):150-167. doi: 10.1038/nprot.2016.168.
  3. Oum YH, Desai TM, Marin M, Melikyan GB. Click labeling of unnatural sugars metabolically incorporated into viral envelope glycoproteins enables visualization of single particle fusion. J. Virol. Methods. 2016. doi: 10.1016/j.jviromet.2016.02.016
  4. Sood C., Marin M, Mason CS and Melikyan GB. Visualization of content release from cell surface-attached single HIV-1 particles carrying an extra-viral fluorescent pH-sensor. PLoS One 2016;11(2):e0148944. doi: 10.1371/journal.pone.0148944.
  5. Desai TM, Marin M, Sood C, Shi J, Nawaz F, Aiken C and Melikyan GB. Fluorescent protein-tagged Vpr dissociates from HIV-1 core after viral fusion and rapidly enters the cell nucleus. Retrovirology. 2015, 12:88. doi: 10.1186/s12977-015-0215-z.
  6. Giroud C, Marin M, Hammonds J, Spearman P and Melikyan GB. P2X1 receptor antagonists inhibit HIV-1 fusion by blocking virus-coreceptor interactions. J. Virol. 2015, 89:9368-9382.
  7. Kondo N, Marin M, Kim JH, Desai TM and Melikyan GB. Distinct requirements for HIV-cell and HIV-mediated cell-cell fusion. J. Biol. Chem. 2015, 290:6558-6573
  8. Padilla-Parra S, Marin M, Kondo N and Melikyan GB. Pinpointing retrovirus entry sites in cells expressing alternatively spliced receptor isoforms by single virus imaging. Retrovirology. 2014 11:47. doi: 10.1186/1742-4690.11-47
  9. Desai TM, Marin M, Chin CR, Savidis G, Brass AL and Melikyan GB. IFITM3 restricts influenza A virus entry by blocking the formation of fusion pores following virus-endosome hemifusion. PLoS Pathog. 2014, 10(4):e1004048. doi: 10.1371/journal.ppat.1004048. PMCID: PMC3974867.
  10. Padilla-Parra S., Marin M., Gahlaut N., Suter R., Kondo N. and Melikyan G.B. Fusion of mature HIV-1 particles leads to complete release of a Gag-GFP-based content marker and raises the intraviral pH. PLoS ONE 2013 8(8): e71002. doi:10.1371/journal.pone.0071002.
  11. Demirkhanyan L, Marin M, Lu W, Melikyan GB. Sub-Inhibitory Concentrations of Human α-defensin Potentiate Neutralizing Antibodies against HIV-1 gp41 Pre-Hairpin Intermediates in the Presence of Serum. PLoS Pathog. 2013 Jun;9(6):e1003431. doi: 10.1371/journal.ppat.1003431. Epub 2013 Jun 13. PMCID: PMC3681749.
  12. Matos P.M., M. Marin, B. Ahn, W. Lam, N.C. Santos, and G.B. Melikyan. Anionic lipids are required for Vesicular Stomatitis Virus G protein-mediated single particle fusion with supported lipid bilayers. J. Biol. Chem. 2013, 288: 12416-12425.
  13. Padilla-Parra S, Matos PM, Kondo N, Marin M, Santos NC, and Melikyan GB. Quantitative imaging of endosome acidification and single retrovirus fusion with distinct pools of early endosomes. Proc. Natl. Acad. Sci. USA, 2012, 109:17627-17632.
  14. Padilla-Parra S, Marin M, Kondo N, Melikyan GB (2012) Synchronized Retrovirus Fusion in Cells Expressing Alternative Receptor Isoforms Releases the Viral Core into Distinct Sub-cellular Compartments. PLoS Pathog. 8(5): e1002694. doi:10.1371/journal.ppat.1002694.
  15. Miyauchi K., Kim Y., Latinovic O., Morozov V., and Melikyan G.B. HIV enters cells via endocytosis and dynamin-dependent fusion with endosomes. Cell, 2009, 137:433-444.