Core Fellowship Curriculum

Fellows Introduction to Research Training (FIRsT) provides pediatric fellows with an overview and introduction to clinical and translational research in the academic setting. Didactic sessions, panel discussions, and interactive opportunities provide forums for fellows to gain an appreciation of the fundamentals of clinical and translational research, biostatistics, epidemiology, the research enterprise, and practical and applied aspects of conducting research. These concepts are conveyed over a 20-hour period, comprised of 4-hour sessions over 5 days, annually following the general pediatrics board examination.

At the completion of FIRsT, the fellow will understand the:
  1. Principles of use of biostatistics in research including the types of variables, data distribution, hypothesis testing, statistical tests, measures of association, regression, diagnostic tests, systematic review and data analysis.
  2. Principles of epidemiology and clinical research design including study types, bias and confounding, causation, incidence and prevalence, screening, decision analysis, cost-benefit analysis, cost-effective analysis, outcome analysis, and sensitivity analysis.
  3. Application of research to clinical practice including assessment of study design, performance and analysis (internal validity), assessment of generalizability (external validity), application of information for patient care, and interpreting the medical literature.
  4. Initial steps for embarking on a research study including developing a CV, finding a mentor, developing a protocol and a budget, submitting a study for Institutional Review Board (IRB) review, and utilizing departmental and university resources for conducting research.
2012 FIRsT: Fellows Introduction to Research Training


FIRsT Course Director:
  • Andi L. Shane, MD, MPH, MSc, Assistant Professor of Pediatrics, Infectious Diseases, SOM
FIRsT Lecturers and Presenters:
  • Valerie Biousse, MD, Professor of Ophthalmology and Neurology and Cyrus H. Stoner Professor of Ophthalmology, SOM,
  • Beau B. Bruce, MD, PhD(c), MSc, Assistant Professor of Ophthalmology and Neurology, SOM
  • Andres Camacho, MD, MSc, Assistant Professor of Pediatrics, Infectious Diseases, SOM
  • Amy Dunn, MD, Assistant Professor of Pediatrics, Hematology-Oncology, SOM
  • Stacy Heilman, PhD, Director of Programs, Department of Pediatrics, SOM
  • Courtney McCracken, PhD(c), Dept. of Pediatrics, SOM
  • Shannon Meeks, MD, Assistant Professor of Pediatrics, Hematology-Oncology, SOM
  • Azhar Nizam, MS, Senior Associate, Biostatistics, RSPH
  • Marc J. Overcash, Assistant Dean, School of Medicine, IT Deputy Chief Information Officer Matt Paden, MD, Assistant Professor of Pediatrics, Critical Care, SOM
  • Amelia C. Randall Perszyk, Sponsored Research Administrator, DOP, SOM
  • Susan Ray, MD, Professor of Medicine, Infectious Diseases., SOM
  • Mia S. White, MILS, AHIP, Medical Education Informationist, Woodruff Health Sciences Center Library
  • Marianne McPherson Yee, MD, MSc, Assistant Professor of Pediatrics, Hematology-Oncology, SOM
Course Description:
FIRsT will provide pediatric fellows with an overview and introduction to clinical and translational research in the academic setting. Didactic sessions, panel discussions, and interactive opportunities will provide forums for fellows to gain an appreciation of the fundamentals of clinical and translational research, biostatistics, epidemiology, the research enterprise, and practical and applied aspects of conducting research. These concepts will be conveyed over a 20-hour period, comprised of 4-hour sessions for 5 days during the week of October 29-November 2, 2012 following the general pediatrics board examination.

Objectives:
At the completion of FIRsT, the fellow will understand the:
  1. Principles of use of biostatistics in research including the types of variables, data distribution, hypothesis testing, statistical tests, measures of association, regression, diagnostic tests, systematic review and data analysis.
  2. Principles of epidemiology and clinical research design including study types, bias and confounding, causation, incidence and prevalence, screening, decision analysis, cost-benefit analysis, cost-effective analysis, and outcome analysis, sensitivity analysis
  3. Application of research to clinical practice including assessment of study design, performance, and analysis (internal validity), assessment of generalizabilty (external validity), application of information for patient care, and using the medical literature.
  4. Initial steps for embarking on a research study including developing a CV, finding a mentor, developing a protocol and a budget, submitting a study for Institutional Review Board (IRB) review, and utilizing the departmental and university resources for conducting research.
References:
  1. Hulley SB, Cummings SR, Browner WS, Grady DG, Newman TB. Designing Clinical Research, 3rd edition, Lippincott Williams & Wilkins, 2006
  2. Howard Hughes Medical Institute, Making the Right Moves, available at http://www.hhmi.org. Will be provided as a portable document file downloaded onto a flash drive.
  3. PowerPoint presentations to accompany faculty presentations
Seminar Topics:
  • Introduction – The fellowship research experience and Got SOC? Requirements for a Scholarship Oversight Committee – Andi Shane
  • NIH biosketch, personal statement, SOM CV format – Andi Shane and Stacy Heilman
  • Epi I: study types, bias and confounding, causation, incidence and prevalence - Beau Bruce
  • Epi II: sensitivity analyses, diagnostic tests and screening – Beau Bruce
  • Epi III: data management options – Beau Bruce
  • How to be mentored and how to manage your mentor - Valerie Biousse
  • Biostats I: variables, data distribution, hypothesis testing – Azhar Nizam
  • Biostats II: statistical tests, measures of association – Azhar Nizam
  • Biostats III: regression - Azhar Nizam
  • Biostats IV: time to events analysis - Azhar Nizam
  • Fellow research experiences and transition to life after fellowship –Andres Camacho, Amy Dunn,Shannon Meeks, Marianne Yee, and Matt Paden
  • Utilizing Electronic Software for Managing References and Bibliographies: EndNote- Mia White
  • Navigating the Institutional Research Board(s) and CITI – Andi Shane
  • Information security and privacy – Marc Overcash
  • RedCap for Data Management – Courtney McCracken
  • ACTSI Resources and manuscript review checklist – Andi Shane
  • Hypothesis and specific aims – Andi Shane
  • Finding funding – Stacy Heilman and Andi Shane
  • Basic budgets 101 – Amelia Randall Perszyk
  • Time management and work-life balance – Susan Ray
  • Recap and evaluation – Andi Shane