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Faculty
  
  
   Nael A. McCarty, PhD
Associate Professor of Pediatrics, Emory University School of Medicine
Adjunct Assoc. Prof. of Physiology, Emory Univ. School of Medicine
Adjunct Assoc. Prof. of Applied Physiology, Georgia Inst. of Tech
Adjunct Assoc. Prof. of Biology, Georgia Inst. Of Tech
Associate Director for Research, Emory University Cystic Fibrosis Center
Member, Petit Inst. for Bioengineering & Bioscience, Georgia Inst. of Tech
Associate Professor of Biology, Georgia Institute of Technology, (tenured)
Adjunct Assoc. Prof. of Chemistry & Biochemistry, Georgia Inst. of Tech

Mailing Address
Emory University School of Medicine
Department of Pediatrics
Division of Pulmonology
2015 Uppergate Drive, NE
Atlanta, GA 30322

Contact Information
Phone: 404-727-3654

Education/Training
  • Undergraduate: B.S. in Biology, University of Kansas 1983
  • Graduate School: M.S. in Marine Biology, University of North Carolina at Wilmington 1987; Ph.D. in Cell Physiology, Univ. of TX Health Science Center at Houston 1990
  • Postgraduate Training: California Institute of Technology, Research Fellow in Biology 1990-1993
Prior Positions
  • Investigator,, Center for Cell and Molecular Signaling, Emory Univ. School of Medicine 1995-2001
  • Adjunct Assistant Prof., Dept. of Pediatrics, Emory University School of Medicine 1995-2001
  • Assistant Professor, Dept. of Physiology, Emory University School of Medicine 1994-2001
  • Senior Research Fellow in Biology, California Institute of Technology, Pasadena, CA 1993-1994
Manuscript Reviewer
  • Am. J. Physiol., 1989-
  • J. Gen. Physiol., 1992-
  • Biophys. J., 1994–
  • Receptors Channels, 1994–1997
  • Mol. Pharm., 1995–
  • Hypertension, 1999–
  • J. Biol. Chem., 2000-
Publications/Presentations/Book Chapters
  • McCarty, N.A. and R.G. O’Neil (1990) Dihydropyridine-sensitive cell volume regulation in renal proximal tubule: the calcium window. Am. J. Physiol., Renal 259:F950-F960.
  • McCarty, N.A. and R.G. O’Neil (1991) Calcium-dependent control of volume regulation in renal proximal tubule cells. I. Swelling-activated Ca2+ entry and release. J. Membr. Biol. 123:149-160
  • McCarty, N.A. and R.G. O’Neil (1991) Calcium-dependent control of volume regulation in renal proximal tubule cells. II. Roles of dihydropyridine-sensitive and -insensitive Ca2+ entry pathways. J. Membr. Biol. 123:161-170.
  • Kahn, A.M., E.J. Cragoe, Jr., J.C. Allen, C.L. Seidel, S.S. Navran, R.G. O’Neil, N.A. McCarty, and H. Shelat (1992) Effects of serotonin on intracellular pH and contraction in vascular smooth muscle. Circ. Res. 71:1294-1304.
  • McCarty, N.A., S. McDonough, B.N. Cohen, J.R. Riordan, N. Davidson, and H. Lester (1993) Voltage-dependent blockade of the cystic fibrosis transmembrane conductance regulator by two closely related arylaminobenzoates. J. Gen. Physiol. 102:1-23.
  • Uezono, Y., J. Bradley, C. Min, N.A. McCarty, M. Quick, JR. Riordan, C. Chavkin, K. G. Zinn, H. A. Lester, and N. Davidson (1993) Receptors that couple to 2 classes of G proteins increase cAMP and activate CFTR expressed in Xenopus oocytes. Receptors Channels 1:233-241.
  • McDonough, S., N. Davidson, H.A. Lester, and N.A. McCarty (1994) Novel pore-lining residues in CFTR that govern permeation and open channel block. Neuron 13:623-634.
  • Walker, L., C.J. Venglarik, G. Aubin, M. Weatherly, N.A. McCarty, B. Lesnick, F. Ruiz, J.P. Clancy, and E.J. Sorscher (1997) Relationship between airway ion transport and a mild pulmonary disease mutation in CFTR. Am. J. Respir. Crit. Care Med 155: 1684-1689.
  • Zhang, Z.-R., S. Zeltwanger, and N.A. McCarty (2000a) Direct comparison of NPPB and DPC as probes of CFTR expressed in Xenopus oocytes. J.Membr. Biol. 175: 35-52
  • Zhang, Z.-R., S. I. McDonough, and N.A. McCarty (2000b) Interaction between permeation and gating in a putative pore-domain mutant in CFTR. Biophys. J. 79: 298-213.
  • Smith, S.S., F. Sun, T.E. Kriewall, Z.-R. Zhang, N.A. McCarty, and D.C. Dawson (2001) CFTR: Covalent and non-covalent modification suggests a role for fixed charges in anion conduction. J. Gen. Physiol. 118:407-431
  • McCarty, N.A., and Z.-R. Zhang (2001) Identification of a region of strong discrimination in the pore of CFTR. Am. J. Physiol., Lung 281:L852-L867
  • Zhang, Z.-R., S. Zeltwanger, S.S. Smith, D.C. Dawson, and N.A. McCarty (2002) Voltage-sensitive gating induced by a mutation in the fifth transmembrane domain mutant of CFTR. Am. J. Physiol., Lung 282:L135-L145.
  • N.A. McCarty, T.A. Standaert, M. Teresi, C. Tuthill, J. Launspach, T.J. Kelly, L.J.H. Milgram, K.A. Hilliard, W.E. Regelmann, M.R. Weatherly, M. L. Aitken, M. W. Konstan, and R.C. Ahrens (2002) A phase I trial of CPX in adult patients with mild cystic fibrosis. Ped. Pulmonol. 33:90-98.
  • R.C. Ahrens, T.A. Standaert, J. Launspach, S.-H. Han, M.E. Teresi, M.L. Aitken, T.H. Kelly, K.A. Hilliard, L.J.H. Milgram, M.W. Konstan, M.R. Weatherly, and N.A. McCarty (2002) Variability of outcome measures in multicenter clinical trials for cystic fibrosis. Ped. Pulmonol. 33:142-150.
  • Tucker, T.A., K. Varga, Z. Begok, N.A. McCarty, J.F. Collawn, L.M. Schweibert, and E.M. Schwiebert (2003) Transient transfection of polarized epithelial monolayers with CFTR and reporter genes using efficacious lipid reagents. Am. J. Physiol., Cell 284:791-805
  • Zhang, Z.-R., S. Zeltwanger, and N.A. McCarty (2004a) Steady-state interactions of glibenclamide with CFTR: Evidence for multiple sites. J. Membr. Biol. 199: 15-28
  • Fuller, M.D., Z.-R. Zhang, G. Cui, J. Kubanek, and N.A. McCarty (2004) Inhibition of CFTR channels by a peptide component of scorpion venom. Am. J. Physiol. (Cell) 287:C1328-1341
  • Zhang, Z.-R., G. Cui, S. Zeltwanger, and N.A. McCarty (2004b) Time-dependent interactions of glibenclamide with CFTR: Kinetically complex block of macroscopic currents. J. Membr. Biol. 201:139-155.
  • Liu, X., Z.-R. Zhang, J. Billingsley, M.D. Fuller, N.A. McCarty, and D.C. Dawson (2004) CFTR: A cysteine at position 338 senses a positive electrostatic potential in the pore. Biophys. J. 87: 3826-3841
  • Zhang, Z.-R., G. Cui, X. Liu, B. Song, D.C. Dawson, and N.A. McCarty (2005) Determination of the functional unit of the CFTR chloride channel: One polypeptide forms one pore. J. Biol. Chem. 280:458-468.
  • Thompson, C.H., D.M. Fields, Olivetti, P.R., M.D. Fuller, Z.-R. Zhang, and N.A. McCarty (2005) Inhibition of ClC-2 Cl- channels by a peptide component of scorpion venom. J. Membr. Biol. 208: 65-76
  • Fuller, M.D., Z.-R. Zhang, G. Cui, and N.A. McCarty (2005) The block of CFTR by scorpion venom is state-dependent. Biophys. J. 89: 3960-3975.
  • Zhang, Z.-R., B. Song, and N.A. McCarty (2005) State-dependent chemical reactivity of an engineered cysteine reveals conformational changes in the outer vestibule of CFTR. J. Biol. Chem. 280:41997-42003.
  • Dawson, D.C., X. Liu, Z.-R. Zhang, and N.A. McCarty (2003) Anion conduction in CFTR: mechanisms and models. In: “The CFTR Chloride Channel”, K. Kirk and D.C. Dawson, eds., Landes Publishing, Georgetown, TX, pp. 1-34
  • Cui, G., M.D. Fuller, C.H. Thompson, Z.-R. Zhang, and N.A. McCarty (2007) Recording currents from channels and transporters in macropatches. In: Patch-Clamp Analysis: Advanced Techniques, 2nd Ed., W. Walz, editor, Humana Press, Inc., Totowa, NJ
Professional/Scientific Societies/Committees
  • Society of General Physiologists
  • American Physiological Society
  • Biophysical Society, Chair of Membrane Biophysics Subgroup, 2006-2007
  • Research and Research Training Committee, Cystic Fibrosis Foundation, Member, 2007-2009
  • Special Emphasis Panel, ZRG1 BST-Q, NIH, “Targeting Protein Folding”, Member, 6/2007
  • Membrane Biophysics Subgroup of the Biophysical Society, Chairman, 2006-2007
  • Ad hoc Study Section, ICP1 (FIRCA program), NIH, Member, 2006
  • US-Israel Binational Science Foundation, External reviewer, 2006
  • U.S. Army Research Office, External reviewer, 2006
  • Member, Special Emphasis Panel, ZRG1-BST-L, NIH
  • Special Emphasis Panel, ZDK1 IRG, NIH, Member, 2005
  • Special Emphasis Panel, MDCN-A IRG, NIH, Member, 2004, ‘05, ‘06
  • NSF, External Grant Reviewer, 2004, ’05, ‘06
  • Ad hoc Study Section, GM-B IRG, NIDDK/NIH, Member, 2002
  • Cellular Cardiovascular Physiology and Pharmacology 2 Study Section, American Heart Association, National Center, Member, 2001 - 2003
  • Cystic Fibrosis Foundation, ad hoc External Grant Reviewer, 2000 - 2006
  • Cystic Fibrosis Therapeutic Development Center at University of North Carolina, Affiliate Member, 1998–
  • Canadian Cystic Fibrosis Foundation, External Grant Reviewer, 1996-
Honors/Awards
  • Hesburgh Teaching Fellows Program, Georgia Institute of Technology, 2006
  • CETL/BP Junior Faculty Teaching Excellence Award at Georgia Institute of Technology, 2005
  • Established Investigator of the American Heart Association, 2001-2004
  • NIH Certified Clinical Investigator, 2000
  • Individual National Research Service Award, N.I.H., Postdoctoral Fellowship, 1990
  • Drown Foundation Postdoctoral Fellowship in Molecular Neurobiology, California Institute of Technology,Division of Biology, 1990
  • Proctor and Gamble Professional Opportunity Award, Renal Physiology Section, 1989
  • Sigma Xi, Grant-in-Aid of Research, 1984
  • Grad. Teaching Assistantship (competitive), Univ. of North Carolina at Wilmington, 1983 - 1985
  • Tuition Scholarship (competitive), University of North Carolina at Wilmington, 1983, 1984


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