Rana Chakraborty MD
Acting Asc Prof
Department of Pediatrics, Emory University School of Medicine
2015 Uppergate Dr. NE
Atlanta , GA 30322
Room: ECC Building
Main Phone: 404-727-4972
Associate Professor of Pediatrics
Director, Ponce Family and Youth Clinic
Division of Infectious Diseases
Emory University School of Medicine
Areas of Interest/Research:
Dr. Rana Chakraborty has been an Associate Professor of Pediatrics in the Division of Pediatric Infectious Diseases since September 2008, having previously completed Pediatric ID training in The Bronx, NY, Newark NJ, Oxford, England and Nairobi, Kenya. His interests include understanding the immunovirology of HIV infection in children, Pediatric HIV care and prevention of mother-to-child transmission of HIV. He is Director of the Pediatric center at the Ponce clinic - the largest facility in the state of Georgia offering care to HIV-infected infants, children, adolescents and their families.
Current areas of research include eliciting potential correlates of protection at the placental interface and potential application to HIV vaccine development, and drug metabolism of antiretroviral therapy in HIV-infected adolescents and children. In both fields there is a relative paucity of scientific studies and evidence-based literature.
Prior to coming to Emory University, Dr Chakraborty worked as a Consultant in Pediatric ID at St George's Hospital, London and developed and published UK guidelines on Pediatric HIV care including management of opportunistic infections and prevention of mother-to-child transmission of HIV. He sits on a number of national and international committees including the Children`s HIV Association of the UK, the Committee on Pediatric AIDS under the AAP and The DHHS Panel on Treatment of HIV-Infected Pregnant Women and Prevention of Perinatal Transmission.
Areas of Research Interest: HIV, Pediatric Immunology, Cellular Immunology, Adolescent HIV, Prevention of Mother-to-Child Transmission of HIV
Primary research interest and efforts: Pediatric Immunology: Characterizing cell mediated responses to primary vaccinations in healthy infants and toddlers. Prevention of Mother-to-Child Transmission of HIV: Characterization of Placental Antigen Presenting Cells
Collaborations: Emory Vaccine Center; Byeongwong Song's lab at the ECC, the Spearman lab at the ECC
Describe project Prevention of MTCT of HIV-1 provides an excellent model to identify correlates of protection from infection. We are examining evidence of infection and immunity in antigen presenting cells at the placental interface in HIV-1-exposed and unexposed newborns.
The ability of HIV-1 to replicate in these cells will be assessed in a tissue culture model. The role of innate antiviral molecules in limiting replication within otherwise susceptible placental cells will be defined in this tissue culture model. Reduced viral replication may reflect abrogated local immune activation. We will therefore examine placental tissue for the presence of T regulatory cells (Tregs) and their potential role in preventing MTCT of HIV-1. Such observations may contribute to HIV-1 vaccine development and have relevance to the protective role of the placenta against the multitude of potentially invasive pathogens encountered during pregnancy.