(A research study for wheezing toddlers ages 12-71 months)
APRIL - Azithromycin for Preventing the development of upper Respiratory tract Illness into Lower respiratory tract symptoms in children And OCELOT - Oral Corticosteroids for treating Episodes of significant LOwer respiratory Tract symptoms in children
The first part of this study (APRIL) is to see if giving Azithromycin (or placebo) at the first signs of wheezing and/or coughing will decrease the incidence of more serious asthma symptoms.
The second part of this study (OCELOT) examines the participants whose symptoms did not improve after completing the APRIL therapy. Not all participants will receive the OCELOT therapy, which is Prednisolone (or placebo).
During the study, there are several questionnaires, physical exams, a blood test and nasal swabs. Parents will be asked to complete diary cards.
Eligible participants will receive free asthma education, allergy testing, physical exams, asthma medications and supplies (such as nebulizers or aero chambers) and monetary compensation for each completed study visit.
Participation in this study will require up to 12 study visits and 9 study telephone calls over about 18 months. The first visit will last 2½ to 3 hours, the second visit will last 1-2 hours, and the other visits will be about 1 hour each. The telephone calls will last less than 15 minutes each.
If you or someone you know is interested in learning more about the APRIL/OCELOT study, please contact Jennifer Dodds 404-727-5176 or firstname.lastname@example.org.